Parkinson's Clinical Trials: What's Recruiting and How to Take Part

What is EJS ACT-PD, and can I join?

The Edmond J Safra Accelerating Clinical Trials in Parkinson's Disease (EJS ACT-PD) study is the largest Parkinson's trial ever run in the UK. It's a "platform" trial: several drugs are tested at the same time against one shared placebo group, and new drugs can be added as others finish. That makes the research faster and more efficient.

• It opened to participants in October 2025 and is recruiting now.
• It tests telmisartan and terazosin, two existing medicines that might slow or stop Parkinson's progression.
• A third drug, ursodeoxycholic acid (UDCA), is planned to be added in 2026. When this page was last updated, it had not yet been confirmed as open.
• It aims to recruit about 1,600 people with Parkinson's at more than 40 sites across the UK. Sites are still opening, so check which ones are near you.
• Participants can attend clinic visits or take part partly from home, and trial medication can be sent to your home.
• You need to live in the UK to take part. The trial website lists the full eligibility criteria.

This study focuses on slowing the disease down, not only on easing symptoms.

Learn more: trial website · ClinicalTrials.gov (NCT07207057) · Cure Parkinson's · Parkinson's UK

Can I help research without testing a new drug?

Yes. Two large studies collect information instead of testing a treatment, and both are open now. They also help match people with trials that do test new treatments.

PPMI

The Parkinson's Precision Medicine Initiative (PPMI), run by the Michael J. Fox Foundation, is a landmark study open to adults with or without Parkinson's. It follows people over many years to understand how Parkinson's starts and changes. In May 2026 it was renamed from "Parkinson's Progression Markers Initiative", so you may still see the old name. It's the same study.

• Online: adults in selected countries can sign up at myppmi.org and answer surveys from home.
• In person: about 50 clinics in 12 countries run tests and collect samples.

PD GENEration and PD Trial Navigator

PD GENEration, from the Parkinson's Foundation, offers free genetic testing and genetic counselling to adults diagnosed with Parkinson's. The results can show whether you might qualify for trials aimed at a specific gene.

• It's currently offered in the US, Canada, Israel and several countries in Latin America and the Caribbean. It isn't available in Europe yet.
• Testing can be done at home with a kit, or at a participating clinic.
• PD Trial Navigator is a free service that started in 2025 for PD GENEration participants. Trained navigators explain gene-targeted trials one-to-one and can put you in touch with trial sites.

What happened with the bezisterim (NE3107) trial?

SUNRISE-PD was a Phase 2 trial of bezisterim (NE3107) in people with early Parkinson's who had not yet started levodopa. It ran in the United States, with a hybrid design that allowed some remote participation.

• It is no longer recruiting. 57 people took part for 12 weeks, and the last visit was in May 2026.
• In August 2026 BioVie, the company developing the drug, reported positive top-line results, mainly on a new combined score of motor and non-motor symptoms.
• These results come from the company and haven't been published in a peer-reviewed journal yet. It was a small, short trial, and no larger trial has been announced.

Learn more: ClinicalTrials.gov (NCT06757010) · BioVie's results announcement

What kinds of Parkinson's trials are there?

How do I find a Parkinson's trial near me?

• Talk to your neurologist first. They often know about local studies and can tell you whether one is right for you.
• Search ClinicalTrials.gov for "Parkinson Disease" with the "Recruiting" filter, then narrow it down to your country.
• In the EU, search the public portal of the Clinical Trials Information System (CTIS), which lists trials across the EU and EEA.
• Use the Michael J. Fox Foundation's Fox Trial Finder. It matches you with studies, including ones you can join from home, and lets you contact study teams directly.
• In the UK, Cure Parkinson's keeps a list of recruiting studies.
• In the Americas or Israel, genetic testing through PD GENEration can help you qualify for gene-targeted trials.

What's the short version?

• EJS ACT-PD is the biggest Parkinson's trial recruiting right now, but it's only for people in the UK.
• PPMI and PD GENEration let you help research without testing a new drug.
• The bezisterim trial has finished. Its results are promising but early.
• ClinicalTrials.gov, CTIS and Fox Trial Finder are the easiest places to look for more.